Toxicological Kev Ntsuam Xyuas Ntawm Tshuaj pleev ib ce

Scope ntawm kev ntsuam xyuas

 

(1) Cov khoom lag luam thiab cov khoom siv raw
Cov khoom lag luam: cov tshuaj pleev ib ce zoo tib yam (kev tu tawv nqaij, xim pleev xim, tu, tu plaub hau, tshuaj tsw qab, tshuaj pleev ib ce menyuam yaus, thiab lwm yam), cov tshuaj pleev ib ce tshwj xeeb (qhov chaw dawb, tshuaj pleev thaiv hnub, tiv thaiv plaub hau, tshem tawm pob txuv, plaub hau dyeing, perm, plaub hau tu, plaub hau poob, kev zoo nkauj, deodorization, thiab lwm yam), cov tshuaj pleev ib ce txawv teb chaws.
Cov khoom siv raw: Cov khoom siv tshuaj pleev ib ce tshiab tshiab (cov khoom siv hauv tsev thawj zaug, hloov kho rau kev siv lub hom phiaj / kev noj tshuaj zoo), siab - cov ntaub ntawv raug phom sij (xws li cov hlau hnyav, cov tshuaj hormones, photosensitivity, allergenicity, thiab cytotoxic cov khoom xyaw), thiab cov ntaub ntawv nyob hauv / siab raug.
Cov xwm txheej tshwj xeeb: Kev sau npe / xa cov ntaub ntawv tshiab, kev sau npe ntawm cov tshuaj pleev ib ce tshwj xeeb, ua ntaub ntawv ntawm cov tshuaj pleev ib ce, kev hloov pauv, kev ntsuam xyuas kev nyab xeeb, kev taug qab ntawm qhov tsis zoo, kev ua lag luam pov thawj kev pheej hmoo.

(2) Kev ntsuas qhov khoom thiab qhov xwm txheej

Kev soj ntsuam cov khoom: cov tshuaj pleev ib ce tiav, cov khoom siv raw monomers, cov khoom siv raw khoom sib xyaw, cov txheej txheem tsim khoom muaj feem xyuam rau impurities, ntim cov ntaub ntawv tsiv teb tsaws.

Cov xwm txheej muaj feem xyuam: ua ntej- kev tshuaj xyuas kev nyab xeeb kev lag luam, kev txheeb xyuas cov khoom phom sij, koob tshuaj- kev soj ntsuam kev sib raug zoo, kev txiav txim siab txog kev nyab xeeb (NOAEL/LOAEL), kev npaj cov ntaub ntawv ntsuam xyuas kev nyab xeeb, thiab kev tswj xyuas kev ua raws cai los ntawm Hainan Market Supervision Bureau.

Txoj kev raug: kev sib cuag ntawm daim tawv nqaij (nyob twj ywm / ntxuav tawm), sib cuag qhov muag, daim di ncauj, hu rau mucosal, transdermal absorption, yuam kev qhov ncauj / inhalation

Cov khoom ntsuas tseem ceeb

 

(1) Cov khoom siv ntsuas (cov khoom tiav / cov khoom siv raw)
kuaj mob toxicity
Kev ntsuam xyuas qhov ncauj toxicity: Txiav txim siab LD50 thiab soj ntsuam ib qho kev noj tshuaj lom ntawm qhov ncauj.
Kev kuaj mob toxicity transdermal: Txiav txim siab LD50 thiab soj ntsuam ib leeg ntawm daim tawv nqaij toxicity.
Stimulating / Corrosive Test
Daim tawv nqaij Irritation / Corrosion Test: Ntsuas qhov kev pheej hmoo ntawm daim tawv nqaij erythema, edema, thiab corrosion.
Mob qhov muag khaus/corrosiveness test: rhiab heev rau kev ntsuam xyuas qhov kev pheej hmoo ntawm pob txha, conjunctival, thiab iris puas
Kev kuaj tawv nqaij ua xua (daim tawv nqaij sensitization): kwv yees qhov kev pheej hmoo ntawm kev ua xua qeeb.
Phototoxicity/photosensitivity test (tus mob tshwm sim: muaj UV absorbing Cheebtsam)
Daim tawv nqaij phototoxicity test: Ntsuas cov tawv nqaij toxicity tom qab ultraviolet irradiation (3T3 nruab nrab liab uptake txoj kev).
Kev kuaj tawv nqaij photosensitivity: Ntsuas UV ua rau muaj kev tsis haum tshuaj.

(2) Cov kev pheej hmoo siab tshaj plaws (cov khoom siv tshiab / siab- cov khoom pheej hmoo)
Genotoxicity (mutagenicity) test (yuav tsum tau ua ke)
Chronic toxicity/carcinogenicity test (siab-cov ntaub ntawv txaus ntshai)
Kev ntsuam xyuas Carcinogenicity: Kev ntsuam xyuas ntawm cov kev pheej hmoo carcinogenic Lwm yam kev kuaj tshwj xeeb
Kev ntsuam xyuas ntawm daim tawv nqaij: Txiav txim siab qhov transdermal permeability coefficient (Kp) thiab ntsuas qhov tshwm sim hauv vivo.
Kev ntsuam xyuas tib neeg tsim nyog: Cov khoom lag luam rau cov me nyuam mos / qhov chaw rhiab yuav tsum tau kuaj xyuas lawv qhov kev nyab xeeb tiag tiag rau kev siv.

(3) Cov Khoom Tshwj Xeeb Ntxiv Cov Haujlwm
Cov tshuaj pleev ib ce me nyuam mos thiab me nyuam me: Txhim kho qhov kev ntsuam xyuas ntawm daim tawv nqaij khaus, khaus qhov muag, ua xua, thiab kev loj hlob toxicity, nrog rau kev nyab xeeb nruj.
Qhov muag / di ncauj tshuaj pleev ib ce: Kev ntsuam xyuas tshwj xeeb rau qhov ua kom khaus qhov muag, mucosal irritation, thiab rhiab heev.
Cov tshuaj pleev thaiv hnub / freckle tshem tawm thiab ntxuav cov tshuaj pleev ib ce yuav tsum muaj cov tshuaj tua kab mob, photosensitivity, kev nqus ntawm daim tawv nqaij, thiab kev kuaj mob toxicity subchronic.
Cov plaub hau zas plaub hau / perm / tshuaj tiv thaiv plaub hau poob cov tshuaj pleev ib ce: ua kom muaj tshuaj lom tshuaj lom neeg, kev loj hlob toxicity, thiab ntev - kev ntsuam xyuas ntawm daim tawv nqaij khaus.
 

GB/T 16886.10 Kev soj ntsuam lom ntawm cov khoom siv kho mob - Kev kuaj rau khaus thiab tawv nqaij rhiab heev

GB/T 21763 Test Method for Subchronic Oral Toxicity of Chemicals to Rodents

GB/T 27826 Test Method for Reproductive and Developmental Toxicity of Chemicals

GB/T 27827 Test Method for Acute Oral Toxicity of Chemicals

Zhejiang Gangxin Testing Technology Co., Ltd.

tau tsim nyob rau xyoo 2011. Raws li lub teb chaws siab - thev naus laus zis kev lag luam tau lees paub los ntawm Zhejiang Provincial Higher People's Court ua lub tsev hais plaub txiav txim siab rau kev tsim kho vaj tsev zoo, peb tshwj xeeb hauv kev ntsuas kev ua tau zoo thiab kev soj ntsuam kev nyab xeeb ntawm cov phiaj xwm kev tsim kho, cov cuab yeej tshwj xeeb, kev sib txuas lus pej thuam, electromagnetic ib puag ncig, txuas hniav loj, thiab kev ntsuam xyuas kev nyab xeeb hauv tsev.

Lub tuam txhab muaj ntau tshaj 100 tus kws tshaj lij thiab cov neeg ua haujlwm, tshaj 90% ntawm cov neeg tuav ntau yam nruab nrab thiab cov ntawv pov thawj kev tshaj lij. Nruab nrog cov cuab yeej ntsuas ua tiav muaj nqis tshaj RMB 10 lab, peb txoj kev lag luam npog tag nrho lub tebchaws.